DNA Sticky End Design and Assignment for Robust Algorithmic Self-assembly

Published on: 2013/09/09

Abstract

Theories of the logic and kinetics of algorithmic self-assembly make many idealizations that eliminate complexities and clarify essential insights. But those complexities are still there when one tries to create self-assembling systems in the laboratory. Which ones are most important, what effects do they have, and how can one design molecules and systems to minimize assembly errors? Examining these questions from both biophysical and combinatorial angles lead us to a DNA sequence design algorithm that may perform orders of magnitude better than previous methods.

Authors

Constantine G. Evans and Erik Winfree

File

DNA Sticky End Design and Assignment for Robust Algorithmic Self-assembly.pdf