Integrating DNA strand-displacement circuitry with DNA tile self-assembly

Published on: 2013/06/12

Abstract

DNA tile self-assembly provides a molecular architecture for algorithmically programming the growth of complex but static geometrical structures with molecular precision. DNA strand displacement circuitry provides a molecular architecture for algorithmically programming the temporal dynamics of well-mixed solutions by design of chemical reaction pathways. What might be achieved by integrating them to enable programmable control over spatial and temporal self-organization simultaneously? Here, we use an upstream strand-displacement catalytic circuit to control the timing of a downstream tile-assembly system to isothermally grow DNA nanotubes.

Authors

David Yu Zhang, Rizal F. Hariadi, Harry M. T. Choi, and Erik Winfree

File

Integrating DNA strand-displacement circuitry with DNA tile self-assembly.pdf