Difference between revisions of "Increasing Redundancy Exponentially Reduces Error Rates during Algorithmic Self-Assembly"
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|abstract=Everyone makes mistakes. That applies to molecules too: during self-assembly, for example, sometimes the wrong molecule arrives at the wrong place, and sticks -- resulting in the growth of an ill-formed structure. But there's a solution: double check, triple check, quadruple check. In DNA tile self-assembly theory, there is a natural way to do this, using proofreading tile sets. Here we demonstrate, experimentally, that assembly error rates decrease exponentially with molecular designs that allow increased levels of proofreading. | |abstract=Everyone makes mistakes. That applies to molecules too: during self-assembly, for example, sometimes the wrong molecule arrives at the wrong place, and sticks -- resulting in the growth of an ill-formed structure. But there's a solution: double check, triple check, quadruple check. In DNA tile self-assembly theory, there is a natural way to do this, using proofreading tile sets. Here we demonstrate, experimentally, that assembly error rates decrease exponentially with molecular designs that allow increased levels of proofreading. | ||
|authors=Rebecca Schulman, Christina Wright, and Erik Winfree | |authors=Rebecca Schulman, Christina Wright, and Erik Winfree | ||
| − | |file=[http://www.dna.caltech.edu/Papers/zig-zag-proofreading2015.pdf Increasing Redundancy Exponentially Reduces Error Rates during Algorithmic Self-Assembly] | + | |file=[http://www.dna.caltech.edu/Papers/zig-zag-proofreading2015.pdf Increasing Redundancy Exponentially Reduces Error Rates during Algorithmic Self-Assembly.pdf] |
}} | }} | ||
Latest revision as of 13:05, 22 June 2021
Published on: 2015/05/12
Abstract
Everyone makes mistakes. That applies to molecules too: during self-assembly, for example, sometimes the wrong molecule arrives at the wrong place, and sticks -- resulting in the growth of an ill-formed structure. But there's a solution: double check, triple check, quadruple check. In DNA tile self-assembly theory, there is a natural way to do this, using proofreading tile sets. Here we demonstrate, experimentally, that assembly error rates decrease exponentially with molecular designs that allow increased levels of proofreading.
Authors
Rebecca Schulman, Christina Wright, and Erik Winfree
File
Increasing Redundancy Exponentially Reduces Error Rates during Algorithmic Self-Assembly.pdf
