PH Controlled Assembly of DNA Tiles

Overview

Responsive self-assembling DNA nanostructures generally take intensity or input concentration as inputs, with the responses to these inputs being encoded within the structure itself; however, expanding the possibilities for inputs opens up new applications for self-assembling DNA nanostructures. A pH-controlled DNA catalytic circuit can be used to expand the possible inputs for these systems and give us more control of their assembly. .

Results

The authors created a pH-controlled assembly of DNA tiles through the use of a DNA strand displacement catalytic circuit; this control is achieved by utilizing the pH sensitivity of triplex DNA.